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The targeting and biosafety of ZymA@SiR21 after MI. (a–b) Ex vivo fluorescence images of hearts from sham and MI mice after intravenous administration of ZymA NPs-ICG or ZymA@SiR21-ICG; (c) The effect of ZymA NPs and ZymA@SiR21 on the main organs of mice, scale bar = 100 mm; Comparison of blood inflammatory factors (d) IL-1β, (e) IL-6, (f) TNF-α, (g) IL-10 and (h) TGF-β1 after short-term administration of ZymA NPs and ZymA@SiR21 in mice, Data in (e–i) are expressed as mean ± SD (n = 5). ∗ p < 0.05, ∗∗ p < 0.01.

Journal: Materials Today Bio

Article Title: Natural polysaccharide-nucleic acid nanocomplex alleviates myocardial infarction by driving chronologically programmed macrophage polarization

doi: 10.1016/j.mtbio.2026.102831

Figure Lengend Snippet: The targeting and biosafety of ZymA@SiR21 after MI. (a–b) Ex vivo fluorescence images of hearts from sham and MI mice after intravenous administration of ZymA NPs-ICG or ZymA@SiR21-ICG; (c) The effect of ZymA NPs and ZymA@SiR21 on the main organs of mice, scale bar = 100 mm; Comparison of blood inflammatory factors (d) IL-1β, (e) IL-6, (f) TNF-α, (g) IL-10 and (h) TGF-β1 after short-term administration of ZymA NPs and ZymA@SiR21 in mice, Data in (e–i) are expressed as mean ± SD (n = 5). ∗ p < 0.05, ∗∗ p < 0.01.

Article Snippet: All chemical reagents and biological materials were obtained from commercial suppliers as follows: N,N-Dimethylacrylamide, ZymA, ICG, and FITC were sourced from Macklin Biochemical Co., Ltd. (Shanghai, China).

Techniques: Ex Vivo, Fluorescence, Comparison